In clinical tests, ImmunoCAP technology has been demonstrated to be close to an ideal lab determination where the correlation coefficient is 100% or 1.0.

 

 

In a recent study illustrated above, laboratories evaluated more than 12,000 blinded serum samples containing various levels of specific IgE, using a number of lab tests in order to compare accuracy and precision.

 

ImmunoCAP technology produced the best assessments (0.96-0.98), performing almost as well as the ideal standard. RAST' tests ranged from 0.65 to 0.82. As the researchers concluded, "The ImmunoCAP assay [Pharmacia CAP system] performed well when compared with the standard of an ideal assay, although other assays often did not perform up to this standard." (1)

 

"Given the dilution range used in this study, values of R-Square below approximately 0.80 generally reflect poor performance in the ability to correctly detect levels of specific IgE antibodies. Only ImmunoCAP had consistently acceptable R-Square values, suggesting good performance in their ability to correctly detect the concentrations of specific IgE antibodies across the different samples and allergens." (1)